SARS-CoV PRCV-ISU-1滴鼻气管途径联合感染小猪模型

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The two PRCV pig groups were inoculated with PRCV via the intranasal (i.n.) and intratracheal (i.t.) routes using a total of 1×10^7 PFU of PRCV in 5 ml medium per pig, with 3 ml i.t. and 1 ml i.n. in each nostril. The i.t. inoculation was performed by sedating the pigs followed by an intubation procedure as an alternate to reported procedures. The anti-inflammatory corticosteroid DEX (VEDCO, St. Joseph, MO), was given daily by intramuscular injection at 2 mg/kg body weight (PRCV/DEX and Mock/DEX groups) from postinoculation days 1 to 6 (PID 1 to 6).

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